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Effects of popcorn butter flavorings, diacetyl and 2,3-pentanedione, on isolated airway preparations.

Authors
Zaccone-EJ; Thompson-JA; Shimko-MJ; Fedan-JS
Source
FASEB J 2013 Apr; 27(Meeting Abstracts):1107.16
NIOSHTIC No.
20042865
Abstract
RATIONALE: "Popcorn workers' lung" is a life-threatening, fixed obstructive pulmonary disease caused by inhalation of butter flavoring vapor. Histological evidence from animals exposed by inhalation to the butter flavorings, diacetyl (2,3-butanedione), and a diacetyl substitute, 2,3-pentanedione (acetyl proprionyl), demonstrated vapor-concentration-dependent damage to epithelial cells. Because nothing is known about the effects of diacetyl and 2,3-pentanedione on airway smooth muscle (ASM), we investigated the pharmacological activity of these two flavorings on isolated airways. METHODS: In rat isolated, perfused tracheas, the contractile and relaxant effects of diacetyl and 2,3-pentanedione applied to the serosal and mucosal surfaces of intact and denuded contracted (MCh; 3x10-5 M) tracheas were evaluated. RESULTS: Concentrations of both agents greater than 3 mM resulted in ASM relaxation. Relaxation of the trachea by diacetyl and 2,3-pentanedione was not dependent upon the presence of the epithelium. CONCLUSIONS: Our findings indicate that both flavorings are similar in their effects as ASM relaxants.
Keywords
Lung-disease; Lung; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function; Pulmonary-disorders; Diseases; Vapors; Respiratory-system-disorders; Respiration; Cell-damage; Pharmacology
CODEN
FAJOEC
CAS No.
431-03-8
Publication Date
20130401
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130801
ISSN
0892-6638
NIOSH Division
HELD
Priority Area
Construction
Source Name
The FASEB Journal
State
WV
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