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Cohort mortality study of garment industry workers exposed to formaldehyde: update and internal comparisons.

Authors
Meyers-AR; Pinkerton-LE; Hein-MJ
Source
Am J Ind Med 2013 Sep; 56(9):1027-1039
NIOSHTIC No.
20042858
Abstract
BACKGROUND: To further evaluate the association between formaldehyde and leukemia, we extended follow-up through 2008 for a cohort mortality study of 11,043 US formaldehyde-exposed garment workers. METHODS: We computed standardized mortality ratios and standardized rate ratios stratified by year of first exposure, exposure duration, and time since first exposure. Associations between exposure duration and rates of leukemia and myeloid leukemia were further examined using Poisson regression models. RESULTS: Compared to the US population, myeloid leukemia mortality was elevated but overall leukemia mortality was not. In internal analyses, overall leukemia mortality increased with increasing exposure duration and this trend was statistically significant. CONCLUSIONS: We continue to see limited evidence of an association between formaldehyde and leukemia. However, the extended follow-up did not strengthen previously observed associations. In addition to continued epidemiologic research, we recommend further research to evaluate the biological plausibility of a causal relation between formaldehyde and leukemia.
Keywords
Formaldehydes; Workers; Work-environment; Exposure-levels; Risk-factors; Garment-workers; Blood-disorders; Mortality-rates; Morbidity-rates; Statistical-analysis; Analytical-processes; Epidemiology; Textile-workers; Textiles; Textile-finishing; Author Keywords: formaldehyde; cohort studies; occupational exposure; retrospective studies; leukemia
Contact
Alysha R.Meyers, PhD, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch,The National Institute for Occupational Safety and Health, 4676 Columbia Parkway,R-15,Cincinnati,OH 45226
CODEN
AJIMD8
CAS No.
50-00-0
Publication Date
20130901
Document Type
Journal Article
Email Address
armeyers@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130801
Issue of Publication
9
ISSN
0271-3586
NIOSH Division
DSHEFS
Source Name
American Journal of Industrial Medicine
State
OH; GA
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