Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Urinary follicle-stimulating hormone as a measure of natural fertility in a community cohort.

Authors
Steiner-AZ; Long-DL; Herring-AH; Kesner-JS; Meadows-JW; Baird-DD
Source
Reprod Sci 2013 May; 20(5):549-556
NIOSHTIC No.
20042657
Abstract
High serum follicle-stimulating hormone (FSH) levels have been associated with diminished ovarian reserve; however, the association between high urinary FSH and reduced natural fertility has yet to be established. We sought to characterize the relationship between a single or multiple measurements of early follicular phase urinary FSH and fertility. Women (n = 209), 30 to 44 years old with no history of infertility, who had been trying to conceive for less than 3 months, provided early follicular phase urine. Participants subsequently kept a diary to record bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. A subset of women (N = 95) collected urine on cycle day 3 for up to 6 cycles. Urine was analyzed for FSH and creatinine (cr) corrected. Proportional hazard models were used to calculate fecundability ratios (FRs). Urinary FSH levels across cycles from the same woman were highly correlated (adjusted intraclass correlation = .77); within-woman variance was 3-fold lower than variance among women. Women with an initial urinary FSH level <7 mIU/mg cr exhibited a nonsignificant reduction in the probability of pregnancy (adjusted FR 0.71, 95% confidence interval [CI]: 0.45-1.13), as did women with elevated urinary FSH > / =12 mIU/mg cr; adjusted FR 0.78, 95% CI: 0.46-1.32). Using the most recent or maximum urinary FSH value did not strengthen the association. In the general population, urinary FSH levels appear to be nonlinearly associated with fertility; however, broad CIs indicate a lack of statistical significance. Repetitive testing appears to be of little benefit.
Keywords
Reproductive-system; Reproductive-effects; Women; Fertility; Hormones; Hormone-activity; Urine-chemistry; Pregnancy; Sexual-reproduction; Author Keywords: fecundability; fertility; follicle-stimulating hormone; ovarian reserve; urine
Contact
Anne Z. Steiner, Department of Obstetrics and Gynecology, University of North Carolina, CB#7570, 4001 Old Clinic Building, Chapel Hill, NC 27599, USA
CODEN
JSGIED
Publication Date
20130501
Document Type
Journal Article
Email Address
asteiner@med.unc.edu
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130612
Issue of Publication
5
ISSN
1933-7191
NIOSH Division
DART
Priority Area
Agriculture, Forestry and Fishing
Source Name
Reproductive Sciences
State
NC; OH
TOP