Dermal absorption and cutaneous toxicity of metalworking fluids.
Toxicology of the skin: target organ toxicology series. Monteiro-Riviere NA. ed. New York: Informa Healthcare, 2010 Feb; 29:361-374
Workers in the metal fabrication industry are more often exposed to MWFs and their components such as biocides via the skin that can cause harm to the skin and/ or the entire body if absorbed by the dermal route. This chapter demonstrated why MWFs are still a major occupational concern in the metal machining industry. Several of the many performance additives such as the biocides in MWFs are readily absorbed across the skin and can illicit an inflammatory response. Research in our laboratory has demonstrated that dermal absorption and cutaneous response can be modulated by the presence of other additives in the MWF formulation. Understanding how these various additives interact with each other and the skin barrier will ultimately help inform the development and risk assessment of MWF formulations that afford greater protection to workers in the metal machining industry.
Metal-industry; Metal-industry-workers; Metal-workers; Metalworking; Metalworking-fluids; Metalworking-industry; Skin-exposure; Skin-irritants; Skin-absorption; Risk-analysis
Book or book chapter
Disease and Injury: Allergic and Irritant Dermatitis
Toxicology of the skin
North Carolina State University, Raleigh, North Carolina