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Dermal absorption and cutaneous toxicity of metalworking fluids.

Authors
Baynes-RE; Vijay-V
Source
Toxicology of the skin: target organ toxicology series. Monteiro-Riviere NA. ed. New York: Informa Healthcare, 2010 Feb; 29:361-374
Link
NIOSHTIC No.
20042644
Abstract
Workers in the metal fabrication industry are more often exposed to MWFs and their components such as biocides via the skin that can cause harm to the skin and/ or the entire body if absorbed by the dermal route. This chapter demonstrated why MWFs are still a major occupational concern in the metal machining industry. Several of the many performance additives such as the biocides in MWFs are readily absorbed across the skin and can illicit an inflammatory response. Research in our laboratory has demonstrated that dermal absorption and cutaneous response can be modulated by the presence of other additives in the MWF formulation. Understanding how these various additives interact with each other and the skin barrier will ultimately help inform the development and risk assessment of MWF formulations that afford greater protection to workers in the metal machining industry.
Keywords
Metal-industry; Metal-industry-workers; Metal-workers; Metalworking; Metalworking-fluids; Metalworking-industry; Skin-exposure; Skin-irritants; Skin-absorption; Risk-analysis
Publication Date
20100201
Document Type
Book or book chapter
Editors
Monteiro-Riviere-NA
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISBN No.
9781420079173
Identifying No.
Grant-Number-R01-OH-003669
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
Toxicology of the skin
State
NC; KS; TX
Performing Organization
North Carolina State University, Raleigh, North Carolina
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