Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Exacerbation of symptoms in agricultural pesticide applicators with asthma.

Authors
Henneberger-PK; Liang-X; London-SJ; Umbach-DM; Sandler-DP; Hoppin-JA
Source
Int J Occup Environ Health 2014 May; 87(4):423-432
NIOSHTIC No.
20042628
Abstract
Purpose Exacerbation is a critical event in asthma management. We investigated whether exacerbation of symptoms is associated with farming exposures among agricultural pesticide applicators with asthma. Methods Participants were pesticide applicators with active asthma (wheezing and breathing problems in past 12 months) who completed enrollment questionnaires for the Agricultural Health Study (AHS). Exacerbation of asthma was defined as having visited a hospital emergency room or doctor for an episode of wheezing or whistling in the past 12 months. Exposures of interest were using 36 specific pesticides in the past 12 months and conducting various agricultural activities. Adjusted odds ratios (ORs) were estimated by logistic regression while controlling for potential confounders. Results The 926 AHS adult pesticide applicators with active asthma included 202 (22 %) with exacerbation. Inverse associations with exacerbation were observed for two herbicides [glyphosate, odds ratio (OR) = 0.5, 95 % confidence interval (CI) 0.3, 0.8, and paraquat, OR = 0.3, 95 % CI 0.1, 0.9] and several agricultural activities (repairing engines, grinding metal, driving diesel tractors, and performing veterinary procedures). Only asthma cases with allergies (i.e., doctor-diagnosed hay fever or eczema, 46 %) had positive exacerbation - pesticide associations, with OR = 2.1 (95 % CI 1.1, 4.1) for the herbicide pendimethalin and OR = 10.2 (95 % CI 1.9, 55) for the insecticide aldicarb. Conclusions The inverse associations with two pesticides and specific farm activities are consistent with the possibility that asthma cases prone to exacerbation may avoid exposures that trigger symptoms. Although limited by small sample size and a cross-sectional design, our study suggests that use of specific pesticides may contribute to exacerbation of asthma among individuals with allergies.
Keywords
Agricultural-chemicals; Agricultural-industry; Agricultural-workers; Agriculture; Pesticides; Pesticides-and-agricultural-chemicals; Respiratory-system-disorders; Pulmonary-system-disorders; Bronchial-asthma; Author Keywords: Asthma; Asthma exacerbation; Work-related; Agriculture; Pesticides
Contact
P. K. Henneberger, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, MS 2800, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
IOEHFU
Publication Date
20140501
Document Type
Journal Article
Email Address
pkh0@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
B20130531
ISSN
1077-3525
NIOSH Division
DRDS
Priority Area
Agriculture, Forestry and Fishing
Source Name
International Journal of Occupational and Environmental Health
State
WV; NC
TOP