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Association of the Period3 clock gene length polymorphism with salivary cortisol secretion among police officers.

Authors
Wirth-M; Burch-J; Violanti-J; Burchfiel-C; Fekedulegn-D; Andrew-M; Zhang-H; Miller-DB; Youngstedt-SD; Hebert-JR; Vena-JE
Source
Neuro Endocrinol Lett 2013 Feb; 34(1):27-37
NIOSHTIC No.
20042589
Abstract
OBJECTIVE: This study evaluated whether measures of waking or diurnal cortisol secretion, or self-reported psychological disturbances differed among police officers with a Period3 (PER3) clock gene length polymorphism. METHODS: The cortisol awakening response was characterized via the area under the salivary cortisol curve with respect to the increase (AUCI) or total waking cortisol (AUCG). Diurnal cortisol measures included the slope of diurnal cortisol and the diurnal AUCG. Psychological disturbances were characterized using the Center for Epidemiologic Studies Depression Scale, Impact of Events Scale, and Life Events Scale. RESULTS: Officers with a 4/5 or 5/5 genotype had higher awakening AUCG and greater diurnal cortisol AUCG levels compared to officers with the 4/4 genotype. Among those working more afternoon or night shifts, waking AUCI and AUCG were greater among officers with a 4/5 or 5/5 genotype compared to the 4/4 referents. CONCLUSION: Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants.
Keywords
Law-enforcement-workers; Police-officers; Sleep-deprivation; Sleep-disorders; Genes; Psychological-responses; Psychological-factors; Salivary-glands; Work-intervals; Shift-workers; Genetic-factors; Biostatistics; Circadian-rhythms; Author Keywords: PER3 VNTR; circadian; cortisol; shiftwork; police
Contact
Michael Wirth, MSPH, PhD., Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Suite 200, Columbia, SC, USA
CODEN
NLETDU
Publication Date
20130201
Document Type
Journal Article
Email Address
wirthm@mailbox.sc.edu
Funding Type
Contract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Contract-212-2008-M-24052; B20130531
Issue of Publication
1
ISSN
0172-780X
NIOSH Division
HELD
Priority Area
Public Safety
Source Name
Neuro Endocrinology Letters
State
SC; NY; WV; GA
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