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Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers.

Authors
Wang-Q; Tan-H-S; Ma-X-M; Sun-Y; Feng-N-N; Zhou-L-F; Ye-Y-J; Zhu-Y-L; Li-Y-L; Brandt-Rauf-PW; Tang-N-J; Xia-Z-L
Source
Int J Hyg Environ Health 2013 Jan; 216(1):76-81
NIOSHTIC No.
20042585
Abstract
In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose-response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shandong Province northern China were examined for chromosomal damage in peripheral blood lymphocytes (PBL) using the cytokinesis-blocked micronucleus (CB-MN) assay of DNA damage. The exposed group (3.47 + / = 2.65)(0/00) showed higher micronucleus frequency than the control (1.60 + / = 1.30)(0/00) (P < 0.01). Occupational exposure level based on micronucleus occurrence in all individuals was analyzed with benchmark dose (BMD) methods. The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. Results showed a dose-response relationship between cumulative exposure and MN frequency, and a BMDL of 0.54 mg/m3 and 0.23 mg/m3 for males and females, respectively. Female workers were more susceptible to MN damage than male workers.
Keywords
Workers; Humans; Men; Women; Exposure-levels; Chromosome-damage; Lymphocytes; Genes; Genetics; Statistical-analysis; Chlorides; Dose-response; Monomers; Bioassays; DNA-damage; Risk-factors; Author Keywords: Vinyl chloride monomer; Chromosomal damage; Benchmark dose; Micronucleus
Contact
Zhao-lin Xia, Department of Occupational Health and Toxicology, Box 288, School of Public Health, Fudan University, Shanghai 200032, China
CODEN
IJEHFT
CAS No.
75-01-4
Publication Date
20130101
Document Type
Journal Article
Email Address
zlxia@shmu.edu.cn
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004192; B20130531
Issue of Publication
1
ISSN
1438-4639
Source Name
International Journal of Hygiene and Environmental Health
State
FL; IL
Performing Organization
University of Illinois
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