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Neoplastic-like transformation effect of single-walled and multi-walled-carbon nanotubes compared to asbestos on human lung small airway epithelial cells.

Authors
Wang-L; Stueckle-TA; Mishra-A; Derk-R; Meighan-T; Castranova-V; Rojanasakul-Y
Source
Nanotoxicology 2013 Aug; 8(5):485-507
NIOSHTIC No.
20042545
Abstract
Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known about the long-term carcinogenic effect of CNT. Neoplastic transformation is a key early event leading to carcinogenesis. We studied the ability of single- and multi-walled CNTs to induce neoplastic transformation of human lung epithelial cells compared to asbestos. Long-term (6 month) exposure of the cells to occupationally relevant concentrations of CNT in culture caused a neoplastic-like transformation phenotype as demonstrated by increased cell proliferation, anchorage-independent growth, invasion and angiogenesis. Whole genome expression signature and protein expression analyses showed that single- and multi-walled CNTs shared similar signaling signatures which were distinct from asbestos. These results provide novel toxicogenomic information and suggest distinct particle-associated mechanisms of neoplasia promotion induced by CNTs and asbestos.
Keywords
Nanotechnology; Lung; Lung-disease; Lung-function; Fibrosis; Fibrous-bodies; Exposure-levels; Risk-factors; Carcinogens; Cell-biology; Cell-function; Cellular-function; Humans; Men; Women; Author Keywords: lung; neoplastic transformation; invasion; genome expression; microarray
Contact
Liying Wang, HELD/PPRB, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CAS No.
1332-21-4
Publication Date
20130801
Document Type
Journal Article
Email Address
lmw6@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1743-5390
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Nanotoxicology
State
WV
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