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Regulatory-based nanotoxicology: evolving national strategies, and research to address engineered nanomaterial health risk assessments.

Authors
Boyes-WK; Nadadur-S; Sayre-P; Castranova-V; Dreher-K; Howard-PC; Warheit-DB
Source
Toxicologist 2013 Mar; 132(1):525
NIOSHTIC No.
20042459
Abstract
Engineered nanomaterials are increasingly being developed and incorporated into a variety of products and applications. However, the full development of nanotechnology is hampered by an uncertainty regarding their environmental, health and safety implications, and how these issues will be addressed by responsible regulatory agencies at the federal and state levels. Novel nanoscale materials present a number of scientific and technical challenges for assessing their potential health implications including: exposure and material characterization; adequacy of conventional toxicity testing methods/guidelines; dose metric(s) across the exposure-dose-effects paradigm; and the role of alternative testing approaches to assess their toxicity. This session will bring together scientists from scientific advisory bodies, regulatory agencies and the private sector to present/discuss research needs, strategies, approaches and findings regarding the health effects testing of engineered nanomaterials and nano-enabled products as it relates to regulatory mission(s). Key topics include: assessing nanomaterial toxicity for regulatory and risk assessment applications; the status or role of alternative test methods to screen or prioritize nanomaterials for in vivo toxicity testing, and the extent to which harmonized testing can be achieved for these novel materials. Each speaker will have 10-12 minutes to highlight agency/institutional approaches and regulatory actions regarding the potential for health effects from engineered nanomaterials. The session will conclude with a 15 minute general discussion period. The overall goal is to provide participants with a view of the status of the development of nanomaterial toxicological assessments that would be sufficient to evaluate health and safety for regulatory agencies.
Keywords
Toxicology; Nanotechnology; Risk-analysis; Risk-factors; Quantitative-analysis; Exposure-levels; Analytical-methods; Regulations; Laboratory-testing; Exposure-methods; Testing-equipment; Dosimetry; Dose-response; In-vivo-study; Decision-making; Medical-sciences; Medical-research; Health-standards
Publication Date
20130301
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130502
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
State
NC; DC; WV; AR; DE; TX
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