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Direct interaction between multiwalled carbon nanotubes and the coronary microcirculation.

Authors
Nurkiewicz-TR; Chen-BT; Frazer-D; Mercer-RR; Scabilloni-JF; Castranova-V; Stapleton-PG
Source
Toxicologist 2013 Mar; 132(1):246
NIOSHTIC No.
20042413
Abstract
Recently our collaborative group identified multi-walled carbon nanotube (MWCNT) translocation from the lung to the heart, liver, and kidneys within 24 hours after pulmonary exposure. From this finding, we continued to examine the microvascular ramifications associated with this direct interaction. To model drug delivery platforms, as well as lung migration, MWCNT were injected into the tail vein of rats (25-900 microg, suspended in 900 microL normosol). 24-hours later, coronary arterioles (<170 microm in diameter) from the left anterior descending artery distribution were isolated for reactivity assessments based on responses to transmural pressure (myogenic responsiveness), intraluminal flow (shear stress), phenylephrine (10-9-10-4 M), acetylcholine (10-9-10-4 M), A23187 (10-9-10-5 M), and spermineNONOate (10-9-10-4 M). Myogenic responsiveness was not altered after MWCNT injection. However, MWCNT injection at all concentrations robustly attenuated reactivity. The coronary microvascular dysfunction associated with MWCNT injection is significant, impacting endothelium-dependent, -independent, adrenergic, and flow-mediated dilation pathways. These alterations, in combination with previous findings, indicate that the microvascular impairments that follow MWCNT injection are more severe than those observed after ingestion or inhalation exposure. Studies are currently underway to further evaluate mechanistic differences between these routes of exposure.
Keywords
Toxicology; Nanotechnology; Laboratory-animals; Pulmonary-system; Dose-response; Lung-function; Heart; Cardiopulmonary-function; Cardiovascular-function; Cardiovascular-system; Phenyl-compounds; Phenyls; Cardiac-function
CAS No.
7440-44-0; 59-42-7; 51-84-3
Publication Date
20130301
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130416
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
State
WV; TX
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