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Time course of pulmonary responses to inhaled multiwalled carbon nanotubes.

Authors
Porter-DW; Hubbs-AF; Mercer-RR; Wu-N; McKinney-W; Chen-BT; Wolfarth-MG; Battelli-LA; Scabilloni-JF; Schwegler-Berry-D; Friend-S; Tsuruoka-S; Endo-M; Frazer-D; Castranova-V
Source
Toxicologist 2013 Mar; 132(1):4
NIOSHTIC No.
20042370
Abstract
In the present study, an aerosol of multi-walled carbon nanotubes (MWCNT) was produced with an acoustical generator, and airborne concentration and size distribution was determined. Mice were exposed by whole body inhalation to MWCNT (5 mg/m3, 5 hours/day, 12 days) and pulmonary responses were monitored at 1 day, 2, 4, 12, 24 and 48 weeks post-exposure. Pulmonary responses were investigated using whole lung lavage, histopathology, morphometry, and enhanced darkfield light microscopy studies. MWCNT lung burden was also measured to assess MWCNT clearance. Data indicate that the lung burdens of MWCNT in this study represent lung burdens relevant to estimated human occupational exposures and caused time-dependent pulmonary inflammation, damage and pulmonary fibrosis. Using enhanced darkfield microscopy, MWCNT fibers were found in lavage of the pleural space, parietal pleura, and respiratory muscles of the diaphragm and chest wall. The time course of pulmonary responses and their relationship to MWCNT lung burden and clearance will be discussed.
Keywords
Toxicology; Nanotechnology; Aerosols; Laboratory-animals; Laboratory-techniques; Exposure-assessment; Exposure-levels; Inhalation-studies; Pulmonary-function; Pulmonary-system; Lung-function; Dose-response; Histopathology; Lung-burden; Microscopy; Pulmonary-disorders; Lung-fibrosis; Lung-irritants; Fiber-deposition; Pleural-cavity
CAS No.
7440-44-0
Publication Date
20130301
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130416
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
State
WV; TX
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