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Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model.

Authors
Anderson-SE; Franko-J; Anderson-KL; Munson-AE; Lukomska-E; Meade-BJ
Source
J Immunotoxicol 2013 Jan-Mar; 10(1):59-66
NIOSHTIC No.
20042348
Abstract
Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 28-day exposure, DMC produced a significant decrease in thymus weight at concentrations of 75% and greater. No effects on body weight, hematological parameters (erythrocytes, leukocytes, and their differentials), or immune cell phenotyping (B-cells, T-cells, and T-cell sub-sets) were identified. The IgM antibody response to sheep red blood cell (SRBC) was significantly reduced in the spleen but not the serum. DMC was not identified to be an irritant and evaluation of the sensitization potential, conducted using the local lymph node assay (LLNA) at concentrations ranging from 50-100%, did not identify increases in lymphocyte proliferation. These results demonstrate that dermal exposure to DMC induces immune suppression in a murine model and raise concern about potential human exposure and the need for occupational exposure regulations.
Keywords
Solvents; Chemical-composition; Chemical-properties; Adhesives; Skin; Skin-exposure; Exposure-levels; Exposure-limits; Models; Blood-cells; Animals; Lymph-nodes; Lymphocytes
Contact
Stacey Anderson, PhD, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505
CODEN
JIOMAP
CAS No.
616-38-6
Publication Date
20130101
Document Type
Journal Article
Email Address
sanderson4@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130403
Issue of Publication
1
ISSN
1547-691X
NIOSH Division
HELD
Source Name
Journal of Immunotoxicology
State
WV
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