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Genetic and epigenetic determinants of susceptibility to environmental and occupational toxicants.

Authors
Johnson-VJ; Yucesoy-B
Source
Toxicologist 2013 Mar; 132(1):3
NIOSHTIC No.
20042326
Abstract
The most common chronic disorders are multifactorial in nature, influenced by complex sequences of gene-gene and gene-environment interactions. While gene expression is a dynamic process that varies in response to a myriad of internal and external triggers and the surrounding microenvironment, the epigenetic mechanisms play a key role in mediating environmental influences on gene expression and epistatic interactions. In this respect, the expression of complex phenotypes should be assessed in a functional context that would look at the interplay between environmental, genetic, and epigenetic factors. Recent advances in genetic and epigenetic research offer new opportunities to integrate experimental approaches, including animal models and in vitro/in vivo translational research, with computational strategies to predict such interactions at multiple levels of complexity. The focus of this session will be on current research investigating the role of genetic factors, epigenetic factors, and gene-environment interactions in the development and outcomes of complex diseases caused by environmental and occupational toxicants.
Keywords
Toxicology; Genes; Gene-mutation; Environmental-exposure; Environmental-factors; Animal-studies; In-vitro-studies; In-vivo-studies; Toxins; Genetic-factors; Genetics; Genotoxic-effects; Environmental-hazards; Occupational-diseases; Occupational-exposure; Occupational-hazards; Diseases
Publication Date
20130301
Document Type
Abstract
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130403
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Priority Area
Healthcare and Social Assistance
Source Name
The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
State
NC; WV; TX
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