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Long-term efficacy of a program to prevent beryllium disease.

Authors
Thomas-CA; Deubner-DC; Stanton-ML; Kreiss-K; Schuler-CR
Source
Am J Ind Med 2013 Jul; 56(7):733-741
NIOSHTIC No.
20042317
Abstract
BACKGROUND: In 2000, a manufacturer of beryllium materials and products introduced a comprehensive program to prevent beryllium sensitization and chronic beryllium disease (CBD). We assessed the program's efficacy in preventing sensitization 9 years after implementation. METHODS: Current and former workers hired since program implementation completed questionnaires and provided blood samples for the beryllium lymphocyte proliferation test (BeLPT). Using these data, as well as company medical surveillance data, we estimated beryllium sensitization prevalence. RESULTS: Cross-sectional prevalence of sensitization was 0.7% (2/298). Combining survey results with surveillance results, a total of seven were identified as sensitized (2.3%). Early Program workers were more likely to be sensitized than Late Program workers; one of the latter was newly identified. All sensitization was identified while participants were employed. One worker was diagnosed with CBD during employment. CONCLUSIONS: The combination of increased respiratory and dermal protection, enclosure and improved ventilation of high-risk processes, dust migration control, improved housekeeping, and worker and management education showed utility in reducing sensitization in the program's first 9 years. The low rate (0.6%, 1/175) among Late Program workers suggests that continuing refinements have provided additional protection against sensitization compared to the program's early years.
Keywords
Beryllium-compounds; Beryllium-disease; Workers; Questionnaires; Blood-samples; Surveillance-programs; Sensitization; Humans; Men; Women; Exposure-levels; Respiratory-protection; Skin; Skin-protection; Ventilation; Dust-control; Education; Author Keywords: beryllium; hypersensitivity; safety management; occupational exposure; program evaluation
Contact
Christine R. Schuler, PhD, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Field Studies Branch,1095Willowdale Road,MS 2800,Morgantown,WV 26505
CODEN
AJIMD8
CAS No.
7440-41-7
Publication Date
20130701
Document Type
Journal Article
Email Address
cschuler@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130321
Issue of Publication
7
ISSN
0271-3586
NIOSH Division
DRDS
Source Name
American Journal of Industrial Medicine
State
WV
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