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Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences.

Authors
Golden-GA; Wyatt-TA; Romberger-DJ; Reiff-D; McCaskill-M; Bauer-C; Gleason-AM; Poole-JA
Source
J Biochem Mol Toxicol 2013 Jan; 27(1):77-86
NIOSHTIC No.
20042169
Abstract
Exposure to organic dusts elicits airway inflammatory diseases. Vitamin D recently has been associated with various airway inflammatory diseases, but its role in agricultural organic dust exposures is unknown. This study investigated whether vitamin D reduces organic dust-induced inflammatory outcomes in cell culture and animal models. Organic dust extracts obtained from swine confinement facilities induced neutrophil chemokine production (human IL-8, murine CXCL1/CXCL2). Neutrophil chemokine induction was reduced in human blood monocytes, human bronchial epithelial cells, and murine lung slices pretreated with 1,25-(OH)(2) D(3) . Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet. These findings were associated with reduced tracheal epithelial cell PKCa and PKCe activity and whole lung TLR2 and TLR4 gene expression. Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes.
Keywords
Respiratory-system-disorders; Airway-obstruction; Airway-resistance; Breathing; Organic-dusts; Vitamins; Immune-reaction; Lung-cells; Lung-disorders; Lung-irritants; Pulmonary-function; Pulmonary-system-disorders; Cell-cultures; Agricultural-workers; Agriculture; Dust-exposure; Dust-inhalation; Laboratory-animals; Neutrophils
Contact
Jill A. Poole, Pulmonary, Critical Care, Sleep and Allergy Division, Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5300, USA
CODEN
JBMTFQ
Publication Date
20130101
Document Type
Journal Article
Email Address
japoole@unmc.edu
Funding Type
Cooperative Agreement
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U54-OH-010162; B20130221
Issue of Publication
1
ISSN
1095-6670
Priority Area
Agriculture, Forestry and Fishing
Source Name
Journal of Biochemical and Molecular Toxicology
State
NE
Performing Organization
University of Nebraska
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