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Role of Nrf2 in oxidative stress and toxicity.

Authors
Ma-Q
Source
Annu Rev Pharmacol Toxicol 2013 Jan; 53:401-426
NIOSHTIC No.
20042026
Abstract
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled production of oxidants in normal cells serves useful purposes to regulate signaling pathways. Reactive oxidants are counterbalanced by complex antioxidant defense systems regulated by a web of pathways to ensure that the response to oxidants is adequate for the body's needs. A recurrent theme in oxidant signaling and antioxidant defense is reactive cysteine thiol-based redox signaling. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. Nrf2 controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure. This review discusses the impact of Nrf2 on oxidative stress and toxicity and how Nrf2 senses oxidants and regulates antioxidant defense.
Keywords
Oxidative-processes; Toxic-effects; Metabolism; Stress; Cell-metabolism; Cellular-reactions; Physiological-effects; Physiology; Author Keywords: reactive oxygen species; redox signaling; antioxidant response element; inducer; cytoprotection
CODEN
ARPTDI
Publication Date
20130110
Document Type
Journal Article
Email Address
qam1@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130124
ISSN
0362-1642
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Annual Review of Pharmacology and Toxicology
State
WV
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