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The relationships between pesticide metabolites and neurobehavioral test performance in the Third National Health and Nutrition Examination Survey.

Authors
Krieg-EF Jr.
Source
Arch Environ Occup Health 2013 Jan; 68(1):39-46
NIOSHTIC No.
20042012
Abstract
Regression analysis was used to estimate and test for relationships between urinary pesticide metabolites and neurobehavioral test performance in adults, 20 to 59 years old, participating in the third National Health and Nutrition Examination Survey. The 12 pesticide metabolites included 2 naphthols, 8 phenols, a phenoxyacetic acid, and a pyridinol. The 3 neurobehavioral tests included in the survey were simple reaction time, symbol-digit substitution, and serial digit learning. As the 2,4-dichlorophenol, 2,5-dichlorophenol, and the pentachlorophenol concentrations increased, performance on the serial digit learning test improved. As the 2,5-dichlorophenol concentration increased, performance on the symbol-digit substitution test improved. At low concentrations, the parent compounds of these metabolites may act at acetylcholine and gamma-aminobutyric acid synapses in the central nervous system to improve neurobehavioral test performance.
Keywords
Metabolites; Urinalysis; Pesticides; Neurological-system; Nervous-system-function; Neuromotor-function; Neuromuscular-system; Behavior; Neurotoxic-effects; Humans; Men; Women; Age-groups; Naphthalenes; Phenols; Phenolic-acids; Pyridines; Central-nervous-system
Contact
Edward F. Krieg, National Institute for Occupational Safety and Health, DART, MS-C22, Cincinnati, OH, 45226
CODEN
AEOHAJ
CAS No.
120-83-2; 583-78-8; 87-86-5
Publication Date
20130108
Document Type
Journal Article
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20130124
Issue of Publication
1
ISSN
1933-8244
NIOSH Division
DART
Source Name
Archives of Environmental & Occupational Health
State
OH
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