Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Explaining skin permeation of 2-butoxyethanol from neat and aqueous solutions.

Authors
Bunge-AL; Persichetti-JM; Payan-JP
Source
Int J Pharm 2012 Oct; 435(1):50-62
NIOSHTIC No.
20041933
Abstract
Absorption of 2-butoxyethanol (BE) from neat and aqueous solutions of BE was measured through rat skin in vitro and in vivo and through silicone membranes. Like previous studies in human and guinea pig skin, BE flux increased proportional to BE concentration only when the weight fraction of BE (w(BE))0.8. Experimental values of thermodynamic activity for BE and water in aqueous solutions of BE are presented. Except when the water content in the vehicle is small, skin is fully hydrated and the flux of a BE through it is proportional to the thermodynamic activity of BE. When w(BE)>0.8, there is a sharp drop in the activity-normalized BE flux through skin, which coincides with a decrease in water activity from 0.9 at w(BE)=0.8 to zero for neat BE. These observations are consistent with reduced BE flux arising from skin dehydration. From an analysis of previously published data, the activity-normalized flux of BE through hydrated human skin was determined to be 2-4 mg cm(-2)h(-1), which is in reasonable agreement with predictions of its maximum flux.
Keywords
Animals; Laboratory-animals; Skin; Skin-exposure; Metabolism; Ethylenes; Author Keywords: 2-Butoxyethanol; Dermal absorption; Glycol ethers; Thermodynamic activity; Skin hydration; Activity coefficient models
Contact
Annette L. Bunge, Colorado School of Mines, 1500 Illinois Street, Golden, CO 80401
CODEN
IJPHDE
CAS No.
111-76-2
Publication Date
20121001
Document Type
Journal Article
Email Address
abunge@mines.edu
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007493; B20130124
Issue of Publication
1
ISSN
0378-5173
Source Name
International Journal of Pharmaceutics
State
CO
Performing Organization
Colorado School of Mines
TOP