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The Upper Midwest Health Study: gliomas and occupational exposure to chlorinated solvents.

Authors
Ruder-AM; Yiin-JH; Waters-MA; Carreón-T; Hein-MJ; Butler-MA; Calvert-GM; Davis-King-KE; Schulte-PA; Mandel-JS; Morton-RF; Reding-DJ; Rosenman-KD; Stewart-PA; the Brain Cancer Collaborative Study Group
Source
Occup Environ Med 2013 Feb; 70(2):73-80
NIOSHTIC No.
20041762
Abstract
OBJECTIVES: Occupational exposure to chlorinated aliphatic solvents has been associated with an increased cancer risk, including brain cancer. However, many of these solvents remain in active, large-volume use. We evaluated glioma risk from non-farm occupational exposure (ever/never and estimated cumulative exposure) to any of the six chlorinated solvents-carbon tetrachloride, chloroform, methylene chloride, trichloroethylene, tetrachloroethylene or 1,1,1-trichloroethane-among 798 cases and 1175 population-based controls, aged 18-80 years and non-metropolitan residents of Iowa, Michigan, Minnesota and Wisconsin. Methods Solvent use was estimated based on occupation, industry and era, using a bibliographic database of published exposure levels and exposure determinants. Unconditional logistic regression was used to calculate ORs adjusted for frequency matching variables age group and sex, and age and education. Additional analyses were limited to 904 participants who donated blood specimens (excluding controls reporting a previous diagnosis of cancer) genotyped for glutathione-S-transferases GSTP1, GSTM3 and GSTT1. Individuals with functional GST genes might convert chlorinated solvents crossing the blood-brain barrier into cytotoxic metabolites. RESULTS: Both estimated cumulative exposure (ppm-years) and ever exposure to chlorinated solvents were associated with decreased glioma risk and were statistically significant overall and for women. In analyses comparing participants with a high probability of exposure with the unexposed, no associations were statistically significant. Solvent-exposed participants with functional GST genes were not at increased risk of glioma. CONCLUSIONS: We observed no associations of glioma risk and chlorinated solvent exposure. Large pooled studies are needed to explore the interaction of genetic pathways and environmental and occupational exposures in glioma aetiology.
Keywords
Exposure-levels; Chlorine-compounds; Cancer; Risk-factors; Brain-damage; Carbinols; Age-groups; Solvents; Humans; Men; Women; Genes; Metabolites
Contact
Dr. Avima M. Ruder, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Columbia Parkway, Mailstop R-16, Cincinnati, OH 45226
CODEN
OEMEEM
CAS No.
67-66-3; 75-09-2; 79-01-6; 71-55-6
Publication Date
20130201
Document Type
Journal Article
Email Address
amr2@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20121218C
Issue of Publication
2
ISSN
1351-0711
NIOSH Division
DSHEFS; DART; EID
Priority Area
Manufacturing
Source Name
Occupational and Environmental Medicine
State
OH; MN; IA; WI; MD; MI
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