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Serial evaluations at an indium-tin oxide production facility.

Authors
Cummings-KJ; Suarthana-E; Edwards-N; Liang-X; Stanton-ML; Day-GA; Saito-R; Kreiss-K
Source
Am J Ind Med 2013 Mar; 56(3):300-307
NIOSHTIC No.
20041760
Abstract
BACKGROUND: We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. METHODS: We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. RESULTS: Abnormalities were uncommon at hire. After hire, prevalence of spirometric restriction was 31% (n=14/45), about fourfold higher than expected. Excessive decline in FEV1 was elevated at 29% (n=12/41). Half (n=21/42) had blood indium =5g/l. More recent hires had fewer abnormalities. There was a suggestion that abnormalities were more common among workers with blood indium =5g/l, but otherwise an exposure-response relationship was not evident. Peak dust concentrations were obscured by time averaging. CONCLUSIONS: Evolving lung function abnormalities consistent with subclinical indium lung disease appeared common and merit systematic investigation. Traditional measures of exposure and response were not illustrative, suggesting fresh approaches will be needed. Workplace changes seemed to have had a positive though incomplete impact; novel preventive interventions are warranted.
Keywords
Lung; Lung-disease; Lung-disorders; Surveillance-programs; Pulmonary-function; Exposure-levels; Sampling; Air-contamination; Dust-exposure; Dust-particles; Particulate-dust; Author Keywords: indium; indium-tin oxide; interstitial lung disease; occupational illness; surveillance
Contact
Kristin J. Cummings, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505
CODEN
AJIMD8
CAS No.
71243-84-0
Publication Date
20130301
Document Type
Journal Article
Email Address
kcummings@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20121218C
Issue of Publication
3
ISSN
0271-3586
NIOSH Division
DRDS
Source Name
American Journal of Industrial Medicine
State
WV
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