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Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization.

Authors
Ehrlich-S; Williams-PL; Missmer-SA; Flaws-JA; Berry-KF; Calafat-AM; Ye-X; Petrozza-JC; Wright-D; Hauser-R
Source
Environ Health Perspect 2012 Jul; 120(7):978-983
NIOSHTIC No.
20041751
Abstract
BACKGROUND: Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. In experimental animals, BPA increases embryo implantation failure and reduces litter size. OBJECTIVE: We evaluated the association of urinary BPA concentrations with implantation failure among women undergoing in vitro fertilization (IVF). METHODS: We used online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry to measure urinary BPA concentrations in 137 women in a prospective cohort study among women undergoing IVF at the Massachusetts General Hospital Fertility Center in Boston, Massachusetts. We used logistic regression to evaluate the association of cycle-specific urinary BPA concentrations with implantation failure, accounting for correlation among multiple IVF cycles in the same woman using generalized estimating equations. Implantation failure was defined as a negative serum -human chorionic gonadotropin test (-hCG < 6 IU/L) 17 days after egg retrieval. RESULTS: Among 137 women undergoing 180 IVF cycles, urinary BPA concentrations had a geometric mean (SD) of 1.53 (2.22) g/L. Overall, 42% (n = 75) of the IVF cycles resulted in implantation failure. In adjusted models, there was an increased odds of implantation failure with higher quartiles of urinary BPA concentrations {odds ratio (OR) 1.02 [95% confidence interval (CI): 0.35, 2.95}, 1.60 (95% CI: 0.70, 3.78), and 2.11 (95% CI: 0.84, 5.31) for quartiles 2, 3, and 4, respectively, compared with the lowest quartile (p-trend = 0.06). CONCLUSION: There was a positive linear dose-response association between BPA urinary concentrations and implantation failure.
Keywords
Plastics; Resins; Pregnancy; Epidemiology; Humans; Women; Urinalysis; In-vitro-studies; Fertility; Statistical-analysis; Phenols; Author Keywords: bisphenol A; embryo implantation; fertility; human; reproduction; women
Contact
R. Hauser, Harvard School of Public Health, 665 Huntington Ave., Building I, 14th Floor, Boston, MA 02115
CODEN
EVHPAZ
CAS No.
80-05-7; 108-95-2
Publication Date
20120701
Document Type
Journal Article
Email Address
rhauser@hsph.harvard.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008578; B20121218B
Issue of Publication
7
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
MA; IL; GA
Performing Organization
Harvard University, School of Public Health, Boston, Massachusetts
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