Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Inflammatory biomarkers increase with severity of upper-extremity overuse disorders.

Authors
Carp-SJ; Barbe-MF; Winter-KA; Amin-M; Barr-AE
Source
Clin Sci 2007 Mar; 112(5):305-314
NIOSHTIC No.
20041714
Abstract
MSDs (musculoskeletal disorders) from overuse are common occupational health problems that cause pain, functional loss and loss of work time. The aim of the present study was to determine whether a relationship exists between the severity of early-onset overuse-related MSDs of the upper extremity and serum levels of IL-1beta (interleukin-1beta), TNF-alpha (tumour necrosis factor-alpha), IL-6 (interleukin-6) and CRP (C-reactive protein). Twenty-two subjects with upper-extremity MSDs due to overuse for no longer that 12 weeks were stratified according to the severity of upper-extremity signs and symptoms as determined by a UBMA (upper-body musculoskeletal assessment). Nine asymptomatic subjects also participated. Serum cytokines were analysed using ELISA, and CRP was analysed using a laser nephelometry technique. CRP was strongly correlated, and TNF-alpha, IL-1beta and IL-6 were moderately correlated, with UBMA scores. Only CRP and TNFalpha were significantly associated with UBMA scores in an ordinal logistic regression analysis in which age and BMI (body mass index) were covariates. These results are of clinical importance as they suggest that early-onset overuse-related MSDs may have an inflammatory component. The possibility of using a combination of serum biomarkers to follow the progression of overuse-related MSDs or their response to therapeutic intervention may be of interest to clinical practitioners and should be the focus of future research.
Keywords
Musculoskeletal-system; Musculoskeletal-system-disorders; Workers; Humans; Men; Women; Biomarkers; Blood-analysis; Age-groups; Repetitive-work; Cumulative-trauma; Cumulative-trauma-disorders; Author Keywords: C-reactive protein (CRP); cytokine; interleukin; musculoskeletal disorder; overuse injury; tumour necrosis factor (TNF); upper-body musculoskeletal assessment
Contact
Dr. Ann E. Barr at the Physical Therapy Department, College of Health Professions, Temple University, 3307 North Broad Street, Philadelphia, PA 19140
CODEN
CSCIAE
Publication Date
20070301
Document Type
Journal Article
Email Address
aebarr@temple.edu
Funding Type
Cooperative Agreement
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U01-OH-008599
Issue of Publication
5
ISSN
0143-5221
Source Name
Clinical Science
State
PA
Performing Organization
Temple University, Philadelphia, Pennsylvania
TOP