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Release of beryllium into artificial airway epithelial lining fluid.

Authors
Stefaniak-AB; Virji-MA; Day-GA
Source
Arch Environ Occup Health 2012 Oct; 67(4):219-228
NIOSHTIC No.
20041675
Abstract
Inhaled beryllium particles that deposit in the lung airway lining fluid may dissolve and interact with immune-competent cells resulting in sensitization. As such, solubilization of 17 beryllium-containing materials (ore, hydroxide, metal, oxide, alloys, and process intermediates) was investigated using artificial human airway epithelial lining fluid. The maximum beryllium release in 7 days was 11.78% (from a beryl ore melter dust), although release from most materials was < 1%. Calculated dissolution half-times ranged from 30 days (reduction furnace material) to 74,000 days (hydroxide). Despite rapid mechanical clearance, billions of beryllium ions may be released in the respiratory tract via dissolution in airway lining fluid. Beryllium-containing particles that deposit in the respiratory tract dissolve in artificial lung epithelial lining fluid, thereby providing ions for absorption in the lung and interaction with immune-competent cells in the respiratory tract.
Keywords
Inhalants; Beryllium-compounds; Lung; Immune-reaction; Hydroxides; Metal-dusts; Metallic-dusts; Metallic-compounds; Particulate-dust; Particulates; Respiration; Respiratory-irritants; Respiratory-system-disorders; Pulmonary-system; Pulmonary-system-disorders; Cell-function; Cellular-function; Author Keywords: beryllium; dissolution; respiratory tract; sensitization
Contact
Aleksandr B. Stefaniak, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2800, Morgantown, WV 26505
CODEN
AEOHAJ
CAS No.
7440-41-7
Publication Date
20121017
Document Type
Journal Article
Email Address
AStefaniak@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20121218A
Issue of Publication
4
ISSN
1933-8244
NIOSH Division
DRDS; NPPTL
Source Name
Archives of Environmental & Occupational Health
State
WV
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