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Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study.

Authors
Stapleton-PA; Minarchick-VC; Cumpston-AM; McKinney-W; Chen-BT; Sager-TM; Frazer-DG; Mercer-RR; Sabilloni-J; Andrew-ME; Castranova-V; Nurkiewicz-TR
Source
Int J Mol Sci 2012 Nov; 13(11):13781-13803
NIOSHTIC No.
20041672
Abstract
Engineered nanomaterials have been developed for widespread applications due to many highly unique and desirable characteristics. The purpose of this study was to assess pulmonary inflammation and subepicardial arteriolar reactivity in response to multi-walled carbon nanotube (MWCNT) inhalation and evaluate the time course of vascular alterations. Rats were exposed to MWCNT aerosols producing pulmonary deposition. Pulmonary inflammation via bronchoalveolar lavage and MWCNT translocation from the lungs to systemic organs was evident 24 h post-inhalation. Coronary arterioles were evaluated 24-168 h post-exposure to determine microvascular response to changes in transmural pressure, endothelium-dependent and -independent reactivity. Myogenic responsiveness, vascular smooth muscle reactivity to nitric oxide, and -adrenergic responses all remained intact. However, a severe impact on endothelium-dependent dilation was observed within 24 h after MWCNT inhalation, a condition which improved, but did not fully return to control after 168 h. In conclusion, results indicate that MWCNT inhalation not only leads to pulmonary inflammation and cytotoxicity at low lung burdens, but also a low level of particle translocation to systemic organs. MWCNT inhalation also leads to impairments of endothelium-dependent dilation in the coronary microcirculation within 24 h, a condition which does not fully dissipate within 168 h. The innovations within the field of nanotechnology, while exciting and novel, can only reach their full potential if toxicity is first properly assessed.
Keywords
Nanotechnology; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-disorders; Cardiopulmonary-function; Cardiopulmonary-system; Cardiopulmonary-system-disorders; Inhalants; Animals; Laboratory-animals; Exposure-levels; Aerosols; Lung; Lung-function; Lung-disorders; Toxins; Author Keywords: microcirculation; coronary; arteriole; nanotoxicology; multi-walled carbon nanotube; engineered nanomaterial; translocation
Contact
Timothy R. Nurkiewicz, Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506
CODEN
IJMCFK
CAS No.
10102-43-9
Publication Date
20121101
Document Type
Journal Article
Email Address
tnurkiewicz@hsc.wvu.edu
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B20121218A
Issue of Publication
11
ISSN
1422-0067
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
International Journal of Molecular Sciences
State
WV
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