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Brain organochlorines and Lewy pathology: the Honolulu-Asia aging study.

Authors
Ross-GW; Duda-JE; Abbott-RD; Pellizzari-E; Petrovitch-H; Miller-DB; O'Callaghan-JP; Tanner-CM; Noorigian-JV; Masaki-K; Launer-L; White-LR
Source
Mov Disord 2012 Sep; 27(11):1418-1424
NIOSHTIC No.
20041638
Abstract
Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.
Keywords
Brain-function; Organo-chlorine-compounds; Brain-disorders; Age-factors; Pathology; Long-term-study; Pesticides; Neurological-reactions; Neurological-system; Benzenes; Epoxides; Author Keywords: Parkinsons disease; Lewy body; organochlorines; pesticides
Contact
Dr. G. Webster Ross, MD, VA Pacific Islands Health Care System, 459 Patterson Road, Honolulu, HI 96819, USA
CAS No.
76-44-8; 72-43-5; 319-85-7
Publication Date
20120915
Document Type
Journal Article
Email Address
george.ross@va.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B10242012
Issue of Publication
11
ISSN
1531-8257
NIOSH Division
HELD
Priority Area
Agriculture, Forestry and Fishing
Source Name
Movement Disorders
State
HI; PA; VA; NC; WV; CA; MD
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