Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Effects of gastric bypass surgery on female reproductive function.

Authors
Legro-RS; Dodson-WC; Gnatuk-CL; Estes-SJ; Kunselman-AR; Meadows-JW; Kesner-JS; Krieg-EF Jr.; Rogers-AM; Haluck-RS; Cooney-RN
Source
J Clin Endocrinol Metab 2012 Dec; 97(12):4540-4548
NIOSHTIC No.
20041637
Abstract
Context: Reproductive functionmayimprove after bariatric surgery, although the mechanisms and time-related changes are unclear. Objective: The objective of the studywasto determine whether ovulation frequency/quality as well as associated reproductive parameters improve after Roux en Y gastric bypass surgery. Design: This was a prospective cohort study that enrolled female subjects from 2005 to 2008 with study visits at baseline and then 1, 3, 6, 12, and up to 24 months after surgery. Setting: The study was conducted at an academic health center. Patients: Twenty-nine obese, reproductive-aged women not using confounding medications participated in the study. Main Outcome Measures: The primary outcome was integrated levels of urinary progestin (pregnanediol 3-glururonide) from daily urinary collections at 12 months postoperatively. Secondary outcomes were changes in vaginal bleeding, other biometric, hormonal, ultrasound, dual-energy x-ray absorptiometry measures, and Female Sexual Function Index. Results: Ninety percent of patients with morbid obesity had ovulatory cycles at baseline, and the ovulatory frequency and luteal phase quality (based on integrated pregnanediol 3-glururonide levels) were not modified by bariatric surgery. The follicular phase was shorter postoperatively [6.5 d shorter at 3 months and 7.9-8.9 d shorter at 6-24 months (P < 0.01)]. Biochemical hyperandrogenism improved, largely due to an immediate postoperative increase in serum SHBG levels (P < 0.01), with no change in clinical hyperandrogenism (sebum production, acne, hirsutism). Bone density was preserved, contrasting with a significant loss of lean muscle mass and fat (P < 0.001), reflecting preferential abdominal fat loss (P < 0.001). Female sexual function improved 28% (P = 0.02) by 12 months. Conclusions: Ovulation persists despite morbid obesity and the changes from bypass surgery. Reproductive function after surgery is characterized by a shortened follicular phase and improved female sexual function.
Keywords
Reproductive-system; Reproductive-effects; Women; Weight-factors; Gastrointestinal-system; Surgery; Urinalysis; X-ray-absorption; Hormone-activity
Contact
Richard S. Legro, M.D., Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, 500 University Drive, H103, Hershey, PA 17033
CODEN
JCEMAZ
Publication Date
20121201
Document Type
Journal Article
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B10242012
Issue of Publication
12
ISSN
0021-972X
NIOSH Division
DART
Priority Area
Manufacturing
Source Name
Journal of Clinical Endocrinology and Metabolism
State
PA; OH; NY
TOP