Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.

Authors
Shvedova-AA; Tkach-AV; Kisin-ER; Khaliullin-T; Stanley-S; Gutkin-DW; Star-A; Chen-Y; Shurin-GV; Kagan-VE; Shurin-MR
Source
Small 2013 May; 9(9-10):1691-1695
NIOSHTIC No.
20041531
Abstract
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
Keywords
Nanotechnology; Lung; Lung-disease; Lung-disorders; Lung-cancer; Cancer; Carcinomas; Cell-function; Cellular-function; Cell-biology; Microbiology; Surveillance-programs; Immune-reaction; Immune-system; Author Keywords: Lewis lung carcinoma; myeloid-derived suppressor cells; SWCNT; tumor metastasis
Contact
Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
SMALBC
Publication Date
20130527
Document Type
Journal Article
Email Address
ats1@cdc.gov
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282; B10152012
Issue of Publication
9-10
ISSN
1613-6810
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Small
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
TOP