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Evaluation of individual-based and group-based exposure estimation of microbial agents in health effects associated with a damp building.

Authors
Cho-SJ; Cox-Ganser-JM; Kreiss-K; Park-J-H
Source
J Expo Sci Environ Epidemiol 2013 Jul/Aug; 23(4):409-415
NIOSHTIC No.
20041520
Abstract
We evaluated attenuation in linear associations between microbial exposure and respiratory symptoms occurring when individual measurements of microbial agents were used for estimating employees' exposure compared with group means. Symptoms, which improved when away from the building (building-related, BR), and measurements of culturable fungi, ergosterol, and endotoxin in floor dust were obtained between 2001 and 2007 from four cross-sectional studies on occupants of a water-damaged building. We compared odds ratios from longitudinal health effect models using individual measurements at employees' workstations with those using floor (group) means. Estimated odds for BR respiratory symptoms in group-based analyses increased by 2 to 5 times compared with those from individual-based analyses for culturable fungi and ergosterol, although they were less precise. For endotoxin, we found substantially increased and significant odds in group-based analyses, while we found no associations in individual-based analyses for various symptoms. Our study suggested that the building floor was useful in constructing exposure groups for microbial agents in this water-damaged building for epidemiologic analysis. Our study showed that group-average exposure estimation provides less attenuated associations between exposures to microbial agents and health in damp indoor environments where measurement error and intrinsic temporal variability are often large.
Keywords
Respiratory-system-disorders; Microorganisms; Employee-exposure; Indoor-environmental-quality; Indoor-air-pollution; Fungi; Endotoxins; Dust-analysis; Dust-exposure; Dust-measurement; Dusts; Floors; Biological-effects; Environmental-pollution; Epidemiology; Exposure-assessment; Health-surveys; Questionnaires; Dust-sampling; Environmental-exposure; Analytical-processes; Author Keywords: microbial agent; exposure estimation; group-based; individual-based; damp building
Contact
Dr. Ju-Hyeong Park, Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, MS 2800, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JEAEE9
Publication Date
20130701
Document Type
Journal Article
Email Address
gzp8@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
B10152012
Issue of Publication
4
ISSN
1559-0631
NIOSH Division
DRDS
Priority Area
Services
Source Name
Journal of Exposure Science and Environmental Epidemiology
State
WV
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