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Psychosocial job stress and immunity: a systematic review.

Authors
Nakata-A
Source
Methods Mol Biol 2012 Aug; 934(Part 1):39-75
NIOSHTIC No.
20041482
Abstract
The purpose of this review was to provide current knowledge about the possible association between psychosocial job stress and immune parameters in blood, saliva, and urine. Using bibliographic databases (PubMed, PsychINFO, Web of Science, Medline) and the snowball method, 56 studies were found. In general, exposure to psychosocial job stress (high job demands, low job control, high job strain, job dissatisfaction, high effort-reward imbalance, overcommitment, burnout, unemployment, organizational downsizing, economic recession) had a measurable impact on immune parameters (reduced NK cell activity, NK and T cell subsets, CD4+/CD8+ ratio, and increased inflammatory markers). The evidence supports that psychosocial job stresses are related to disrupted immune responses but further research is needed to demonstrate cause-effect relationships.
Keywords
Job-stress; Psychological-factors; Sociological-factors; Workers; Worker-health; Immune-reaction; Immune-system; Biological-systems; Blood-tests; Urinalysis; Salivary-glands; Cell-function; Cellular-reactions; Work-environment; Work-operations; Work-organization; Work-performance; Worker-motivation; Author Keywords: Psychosocial job stress; Immune system; Psychoneuroimmunology; Systematic review; Work environment
CODEN
MMBIED
Publication Date
20120801
Document Type
Journal Article
Editors
Yan-Q
Fiscal Year
2012
NTIS Accession No.
NTIS Price
ISBN No.
9781627030700
Identifying No.
B09262012
ISSN
1064-3745
NIOSH Division
DART
Priority Area
Services
Source Name
Methods in Molecular Biology. Psychoneuroimmunology: Methods and Protocols
State
OH
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