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Acute vascular effects of nanoparticle infusion in isolated perfused skin.

Authors
Riviere-JE; Leavens-TL; Brooks-JD; Monteiro-Riviere-NA
Source
Nanomedicine 2012 May; 8(4):428-431
NIOSHTIC No.
20041466
Abstract
The majority of studies on the effect of nanomaterials on biological function involves either isolated in vitro cell systems or are concerned with in vivo effects after inhalational or dermal exposure. The current work reports on an intriguing observation of the vascular effects seen in an ex vivo perfused tissue preparation, the isolated perfused porcine skin flap (IPPSF), in studies conducted to assess nanomaterial biodistribution. Compared with a relatively large dataset involving organic chemical infusions (n = 53), infusion of six different nanoparticles of diverse sizes and composition (silica or dextran coated Fe(2)O(3), silica or citrate coated silver, PEG or carboxylated quantum dots [QD]) resulted in statistically significant post-infusion flap weight gain and an increase in arterial perfusion pressure (especially with QD-PEG). In contrast, infusion with nC(60) nanoparticles did not produce these effects. These observations suggest certain nanoparticle infusions may be associated with acute vascular physiologic effects that merit further attention. FROM THE CLINICAL EDITOR: In this study utilizing a perfused porcine skin flap, specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects.
Keywords
Nanotechnology; Biological-function; Cell-function; Inhalants; Skin-exposure; Exposure-levels; Organic-chemicals; Silicates; Physiological-effects; Animals; Author Keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
Contact
Jim E. Riviere, DVM, PhD, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh NC 27607
CODEN
NANOBF
CAS No.
7631-86-9
Publication Date
20120501
Document Type
Journal Article
Email Address
jim_riviere@ncsu.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007555; B09262012
Issue of Publication
4
ISSN
1549-9634
Source Name
Nanomedicine: Nanotechnology, Biology and Medicine
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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