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Development of risk-based nanomaterial groups for occupational exposure control.

Authors
Kuempel-ED; Castranova-V; Geraci-CL; Schulte-PA
Source
J Nanoparticle Res 2012 Sep; 14(9):1029
NIOSHTIC No.
20041385
Abstract
Given the almost limitless variety of nanomaterials, it will be virtually impossible to assess the possible occupational health hazard of each nanomaterial individually. The development of science-based hazard and risk categories for nanomaterials is needed for decision-making about exposure control practices in the workplace. A possible strategy would be to select representative (benchmark) materials from various mode of action (MOA) classes, evaluate the hazard and develop risk estimates, and then apply a systematic comparison of new nanomaterials with the benchmark materials in the same MOA class. Poorly soluble particles are used here as an example to illustrate quantitative risk assessment methods for possible benchmark particles and occupational exposure control groups, given mode of action and relative toxicity. Linking such benchmark particles to specific exposure control bands would facilitate the translation of health hazard and quantitative risk information to the development of effective exposure control practices in the workplace. A key challenge is obtaining sufficient dose-response data, based on standard testing, to systematically evaluate the nanomaterials' physical-chemical factors influencing their biological activity. Categorization processes involve both science-based analyses and default assumptions in the absence of substance-specific information. Utilizing data and information from related materials may facilitate initial determinations of exposure control systems for nanomaterials.
Keywords
Nanotechnology; Risk-analysis; Risk-factors; Exposure-assessment; Hazardous-materials; Hazards; Health-hazards; Health-sciences; Medical-sciences; Decision-making; Occupational-exposure; Occupational-hazards; Control-systems; Control-technology; Work-practices; Safety-measures; Quantitative-analysis; Particulates; Toxic-materials; Analytical-processes; Dose-response; Chemical-indicators; Standards; Physical-properties; Biological-effects; Information-systems; Author Keywords: Risk assessment; Occupational exposure limits; Comparative toxicity; Hazard groups; Exposure control groups; Health effects
Contact
E. D. Kuempel, Education and Information Division, Nanotechnology Research Center (NTRC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, OH, 45226 USA
CODEN
JNARFA
Publication Date
20120901
Document Type
Journal Article
Email Address
ekuempel@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B09112012
Issue of Publication
9
ISSN
1388-0764
NIOSH Division
EID; HELD
Source Name
Journal of Nanoparticle Research
State
OH; WV
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