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Cadmium exposure and neurodevelopmental outcomes in U.S. children.

Authors
Ciesielski-T; Weuve-J; Bellinger-DC; Schwartz-J; Lanphear-B; Wright-RO
Source
Environ Health Perspect 2012 May; 120(5):758-763
NIOSHTIC No.
20041370
Abstract
BACKGROUND: Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes. OBJECTIVE: Our aim was to evaluate associations between urinary cadmium concentration and reported learning disability (LD), special education utilization, and attention deficit hyperactivity disorder (ADHD) in U.S. children using National Health and Nutrition Examination Survey (NHANES) data. METHODS: We analyzed data from a subset of participants in NHANES (1999-2004) who were 6-15 years of age and had spot urine samples analyzed for cadmium. Outcomes were assessed by parent or proxy-respondent report. We fit multivariable-adjusted logistic regression models to estimate associations between urinary cadmium and the outcomes. RESULTS: When we compared children in the highest quartile of urinary cadmium with those in the lowest quartile, odds ratios adjusted for several potential confounders were 3.21 [95% confidence interval (CI): 1.43, 7.17] for LD, 3.00 (95% CI: 1.12, 8.01) for special education, and 0.67 (95% CI: 0.28, 1.61) for ADHD. There were no significant interactions with sex, but associations with LD and special education were somewhat stronger in males, and the trend in the ADHD analysis was only evident among those with blood lead levels above the median. CONCLUSIONS: These findings suggest that children who have higher urinary cadmium concentrations may have increased risk of both LD and special education. Importantly, we observed these associations at exposure levels that were previously considered to be without adverse effects, and these levels are common among U.S. children.
Keywords
Humans; Adolescents; Women; Men; Exposure-levels; Children; Neurological-system; Neuromotor-function; Neuromotor-system; Neuromuscular-system; Neurophysiological-effects; Urinalysis; Mental-health; Environmental-exposure; Chemical-hypersensitivity; Chemical-reactions; Nutrition; Statistical-analysis; Author Keywords: attention deficit hyperactivity disorder; cadmium; learning disability; neurodevelopment; neuropsychological development; NHANES; risk assessment; special education
Contact
Timothy H. Ciesielski, Exposure, Epidemiology, and Risk Program, 401 Park Dr. West, P.O. Box 15677, Boston, MA 02215
CODEN
EVHPAZ
CAS No.
7440-43-9
Publication Date
20120501
Document Type
Journal Article
Email Address
TimothyHCiesielski@gmail.com
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008416; B09112012
Issue of Publication
5
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
MA; IL; OH
Performing Organization
Harvard School of Public Health
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