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Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.

Authors
Tkach-AV; Yanamala-N; Stanley-S; Shurin-MR; Shurin-GV; Kisin-ER; Murray-AR; Pareso-S; Khaliullin-T; Kotchey-GP; Castranova-V; Mathur-S; Fadeel-B; Star-A; Kagan-VE; Shvedova-AA
Source
Small 2013 May; 9(9-10):1686-1690
NIOSHTIC No.
20041340
Abstract
Graphene oxide (GO) and C(60) - or C(60) -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells.T-cells in different ways. While C(60) -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C(60) -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
Keywords
Oxides; Cell-alteration; Cell-function; Cellular-reactions; Antigens; Dose-response; Proteins; Vaccines; Cytology; Immune-reaction; Immune-system; Immune-system-disorders; Author Keywords: antigens; dendritic cells; fullerenes; graphene oxide; immune suppression
Contact
Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown WV 26505, USA
CODEN
SMALBC
Publication Date
20130527
Document Type
Journal Article
Email Address
ats1@cdc.gov
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282; B08292012
Issue of Publication
9-10
ISSN
1613-6810
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Small
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
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