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Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002.

Authors
Gilboa-SM; Desrosiers-TA; Lawson-C; Lupo-PJ; Riehle-Colarusso-TJ; Stewart-PA; van Wijngaarden-E; Waters-MA; Correa-A; National Birth Defects Prevention Study
Source
Occup Environ Med 2012 Sep; 69(9):628-635
NIOSHTIC No.
20041173
Abstract
Objective: To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents and Stoddard solvent during the period from 1 month before conception through the first trimester. Methods: The study population included mothers of infants with simple isolated CHDs and mothers of control infants who delivered from 1997 through 2002 and participated in the National Birth Defects Prevention Study. Two methods to assess occupational solvent exposure were employed: an expert consensus-based approach and a literature-based approach. Multiple logistic regression was used to calculate adjusted ORs and 95% CIs for the association between solvent classes and CHDs. Results: 2951 control mothers and 2047 CHD case mothers were included. Using the consensus-based approach, associations were observed for exposure to any solvent and any chlorinated solvent with perimembranous ventricular septal defects (OR 1.6, 95% CI 1.0 to 2.6 and OR 1.7, 95% CI 1.0 to 2.8, respectively). Using the literature-based approach, associations were observed for: any solvent exposure with aortic stenosis (OR 2.1, 95% CI 1.1 to 4.1) and Stoddard solvent exposure with d-transposition of the great arteries (OR 2.0, 95% CI 1.0 to 4.2), right ventricular outflow tract obstruction defects (OR 1.9, 95% CI 1.1 to 3.3) and pulmonary valve stenosis (OR 2.1, 95% CI 1.1 to 3.8). Conclusions: The authors found evidence of associations between occupational exposure to solvents and several types of CHDs. These results should be interpreted in light of the potential for misclassification of exposure.
Keywords
Humans; Women; Children; Heart; Cardiac-function; Cardiovascular-function; Cardiovascular-system; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cardiovascular-disease; Occupational-exposure; Chlorine-compounds; Chlorides; Organic-solvents; Solvents; Birth-defects; Occupational-exposure; Exposure-levels; Reproductive-effects; Reproductive-hazards; Teratogenesis; Teratogens; Teratology
Contact
Dr Suzanne M Gilboa, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, MS E-86, 1600 Clifton Road, Atlanta, GA 30333
CODEN
OEMEEM
Publication Date
20120901
Document Type
Journal Article
Email Address
sgilboa@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B08012012
Issue of Publication
9
ISSN
1351-0711
NIOSH Division
DSHEFS; DART
Priority Area
Manufacturing
Source Name
Occupational and Environmental Medicine
State
GA; NC; OH; TX; VA; NY; MS; MD; KY
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