Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska.
Reynolds-SJ; Clark-ML; Koehncke-N; von Essen-S; Prinz-L; Keefe-TJ; Mehaffy-J; Bradford-M; Cranmer-B; Davidson-ME; Yang-IV; Burch-JB
J Occup Environ Med 2012 May; 54(5):632-641
OBJECTIVE: Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects. METHODS: We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers. RESULTS: Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction = 0.05). CONCLUSIONS: A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs.
Organic-dusts; Inhalants; Respiratory-system-disorders; Respiration; Respirable-dust; Respiratory-irritants; Agriculture; Agricultural-workers; Endotoxins; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Farmers; Workers; Exposure-levels; Humans; Men; Women; Pesticides; Herbicides; Genes; Genetics; Genetic-factors; Smoking
Stephen J. Reynolds, PhD, CIH, Fellow AIHA, 154B EHB Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Ft Collins, CO 80523
Grant; Cooperative Agreement
Grant-Number-R01-OH-007841; Cooperative-Agreement-Number-U50-OH-008085; B08012012
Journal of Occupational and Environmental Medicine
Colorado State University - Ft. Collins