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Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska.

Authors
Reynolds-SJ; Clark-ML; Koehncke-N; von Essen-S; Prinz-L; Keefe-TJ; Mehaffy-J; Bradford-M; Cranmer-B; Davidson-ME; Yang-IV; Burch-JB
Source
J Occup Environ Med 2012 May; 54(5):632-641
NIOSHTIC No.
20041159
Abstract
OBJECTIVE: Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects. METHODS: We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers. RESULTS: Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction = 0.05). CONCLUSIONS: A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs.
Keywords
Organic-dusts; Inhalants; Respiratory-system-disorders; Respiration; Respirable-dust; Respiratory-irritants; Agriculture; Agricultural-workers; Endotoxins; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Farmers; Workers; Exposure-levels; Humans; Men; Women; Pesticides; Herbicides; Genes; Genetics; Genetic-factors; Smoking
Contact
Stephen J. Reynolds, PhD, CIH, Fellow AIHA, 154B EHB Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Ft Collins, CO 80523
CODEN
JOEMFM
Publication Date
20120501
Document Type
Journal Article
Email Address
Stephen.Reynolds@Colostate.edu
Funding Type
Grant; Cooperative Agreement
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007841; Cooperative-Agreement-Number-U50-OH-008085; B08012012
Issue of Publication
5
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
CO; NE; SC
Performing Organization
Colorado State University - Ft. Collins
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