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Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine.

Authors
Kelly-KA; Miller-DB; Bowyer-JF; O'Callaghan-JP
Source
J Neurochem 2012 Sep; 122(5):995-1009
NIOSHTIC No.
20041150
Abstract
Upregulation of proinflammatory cytokines and chemokines in brain ("neuroinflammation") accompanies neurological disease and neurotoxicity. Previously, we documented a striatal neuroinflammatory response to acute administration of a neurotoxic dose of methamphetamine (METH), i.e. one associated with evidence of dopaminergic terminal damage and activation of microglia and astroglia. When we used minocycline to suppress METH-induced neuroinflammation, indices of dopaminergic neurotoxicity were not affected but suppression of neuroinflammation was incomplete.
Keywords
Brain-function; Diseases; Neurotoxicity; Neurotoxic-effects; Drugs; Corticosteroids; Neurological-diseases; Neurological-reactions; Animals; Laboratory-animals
CODEN
JONRA9
CAS No.
537-46-2
Publication Date
20120901
Document Type
Journal Article
Email Address
jdo5@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B08012012
Issue of Publication
5
ISSN
0022-3042
NIOSH Division
HELD
Priority Area
Public Safety
Source Name
Journal of Neurochemistry
State
WV; AR
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