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Immunological and inflammatory responses to organic dust in agriculture.

Authors
Poole-JA; Romberger-DJ
Source
Curr Opin Allergy Clin Immunol 2012 Apr; 12(2):126-132
NIOSHTIC No.
20041122
Abstract
PURPOSE OF REVIEW: Agriculture represents a major industry worldwide, and despite protection against the development of IgE-mediated diseases, chronic exposure to agriculture-related organic dusts is associated with an increased risk of developing respiratory disease. This article will review the literature regarding new knowledge of important etiologic agents in the dusts and focus on the immunologic responses following acute and repetitive organic dust exposures. RECENT FINDINGS: Although endotoxin remains important, there is an emerging role of nonendotoxin components such as peptidoglycans from Gram-positive bacteria. Pattern recognition receptors including Toll-like receptor 4 (TLR4), TLR2 and intracellular nucleotide oligomerization domain-like receptors are partially responsible for mediating the inflammatory consequences. Repeated organic dust exposures modulate innate and adaptive immune function with a resultant adaptation-like response. However, repetitive exposures cause lung parenchymal inflammation, chronic disease, and lung function decline over time. SUMMARY: The immunological consequences of organic dust exposure in the farming industry are likely explained by the diversity of microbial motifs in dust that can elicit differing innate immune receptor signaling pathways. Whereas initial activation results in a robust inflammatory response, repetitive dust exposures modulate immunity. This can result in low-grade, chronic inflammation, and/or protection against allergic disease.
Keywords
Agriculture; Agricultural-industry; Exposure-levels; Dusts; Dust-particles; Dust-inhalation; Dust-exposure; Respiration; Respiratory-system-disorders; Pulmonary-system; Pulmonary-function; Pulmonary-system-disorders; Pulmonary-disorders; Diseases; Etiology; Immunology; Organic-dusts; Lung; Lung-disease; Lung-disorders; Lung-function; Particulate-dust; Particulates; Farmers; Author Keywords: adaptation; endotoxin; farm; innate immunity; pattern recognition receptors; peptidoglycan; respiratory disease
Contact
Jill A. Poole, Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5300
CODEN
COACCS
Publication Date
20120401
Document Type
Journal Article
Email Address
japoole@unmc.edu
Funding Type
Grant; Cooperative Agreement
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008539; Cooperative-Agreement-Number-U54-OH-010162; B08012012
Issue of Publication
2
ISSN
1528-4050
Priority Area
Agriculture, Forestry and Fishing
Source Name
Current Opinion in Allergy and Clinical Immunology
State
NE
Performing Organization
University of Nebraska
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