Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

An exposure-response analysis of respiratory disease risk associated with occupational exposure to chrysotile asbestos.

Authors
Stayner-L; Smith-R; Bailer-AJ; Gilbert-S; Steenland-K; Dement-J; Brown-D; Lemen-R
Source
Ann Occup Hyg, Inhaled Particles VIII 1997 Jan; 41(Suppl 1):137-141
NIOSHTIC No.
20040999
Abstract
The results from these analyses clearly demonstrate a strong exposure-response relationship between chrysotile exposure and mortality from asbestosis and lung cancer, which is not surprising given the results from previous studies. The exposure-response relationship for lung cancer appeared to be linear on a multiplicative scale, whereas the exposure-response relationship for asbestosis appeared to be sub-linear. There was no statistical evidence for a threshold in either the lung cancer or asbestosis model. Thus the results from this analysis fail to provide any support for arguments that have been made for a threshold for the effects of chrysotile asbestos on lung cancer and asbestosis risks (Browne, 1986). Based on this analysis, the predictions of excess lifetime risk for white males exposed for 45 years at the recently revised OSHA standard of 0.1 fibers cc--1 was predicted to be approximately 5 per 1000 for lung cancer and 2 per 1000 for asbestosis. The lung cancer risks estimated in this analysis were substantially higher than what was observed in previous analyses of Quebec chrysotile miners and millers (McDonald et al., 1980, 1994). The reasons for these widely varying results are not known.
Keywords
Asbestos-fibers; Occupational-exposure; Respiratory-system-disorders; Dose-response; Lung-cancer; Industrial-factory-workers; Asbestos-workers; Mortality-data
CODEN
AOHYA3
Publication Date
19970101
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
ISSN
0003-4878
NIOSH Division
EID; DSHEFS; OD
Source Name
Annals of Occupational Hygiene, Inhaled Particles VIII
State
OH; GA
TOP