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Soluble and particulate activators of complement and granulomatous pulmonary reactions.

Authors
Pearson-DJ; Green-FH; Mentnech-SM
Source
Clin Allergy 1981 Mar; 11(2):111-119
Link
NIOSHTIC No.
20040960
Abstract
In order to test the hypothesis that the histological changes of extrinsic allergic alveolitis result from non-specific activation of the complement cascade we studied pulmonary reactions to equivalent doses of soluble and particulate activators of complement in rats. A single intratracheal instillation of zymosan, a particulate activator of the complement system, produced a florid granulomatous pneumonitis which was maximal at 5 days. This granulomatous reaction did not appear to be associated with the development of hypersensitivity to zymosan. Complement depletion by cobra venom factor did not suppress the granulomatous reaction. Equivalent doses of soluble activators of complement failed to produce any inflammatory changes in the lung. Large doses of immune complex produced an acute, complement dependent, haemorrhagic alveolitis which was maximal at 8 hr and which resolved completely by 48 hr. We conclude that the late granulomatous pulmonary reaction to intra-tracheally administered zymosan is not due to an immune response, or a consequence of direct activation of the alternative pathway of complement, but is of 'foreign body' type. We urge caution in drawing conclusions regarding the pathogenesis of the allergic alveolitides on histological appearances alone.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Lung-disease; Lung-function; Immunology; Allergic-reactions; Laboratory-animals; Animals; Animal-studies
CODEN
CLAGBI
Publication Date
19810301
Document Type
Journal Article
Funding Type
Agriculture
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0009-9090
NIOSH Division
DRDS
Source Name
Clinical Allergy
State
WV
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