Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Interactions of carbon nanotubes with the immune system: focus on mechanisms of internalization and biodegradation.

Authors
Fadeel-B; Shvedova-AA; Kagan-VE
Source
Nanomedicine: Basic and Clinical Applications in Diagnostics and Therapy, Chapter 3: Nanotoxicity. Alexiou-C, ed., Basel: Karger, 2011 Jan; 2:80-87
NIOSHTIC No.
20040895
Abstract
Carbon nanotubes (CNT) are cylinders of one or several coaxial graphite layer(s) with a diameter on the nanometer scale. CNT can be readily functionalized, and exciting studies on the use of CNT as excipients for drug delivery and imaging of disease processes have been reported. On the other hand, CNT were also shown to induce oxidative stress, inflammation, and fibrosis, and animal studies have suggested similarities between the pathogenic properties of certain multiwalled CNT and those of asbestos fibers. Recent studies have disclosed that CNT are susceptible to enzymatic biodegradation, and this observation could hold the key to the safe application of these nanomaterials in biomedicine. Here, we provide a brief overview of pertinent toxicological and biomedical investigations of CNT including recent work on the interaction of CNT with immune-competent cells, focusing on cellular recognition of nanotubes and their enzymatic degradation.
Keywords
Nanotechnology; Oxidative-processes; Oxidative-enzymes; Biomedical-engineering; Enzymes; Enzymatic-effects
CAS No.
7440-44-0
Publication Date
20110101
Document Type
Book or book chapter
Editors
Alexiou-C
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISBN No.
9783805598187
ISSN
1663-0114
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Nanomedicine: Basic and Clinical Applications in Diagnostics and Therapy, Chapter 3: Nanotoxicity
State
WV; PA
TOP