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Pulmonary toxicity, distribution, and clearance of intratracheally instilled silicon nanowires in rats.

Authors
Roberts-JR; Mercer-RR; Chapman-RS; Cohen-GM; Bangsaruntip-S; Schwegler-Berry-D; Scabilloni-JF; Castranova-V; Antonini-JM; Leonard-SS
Source
J Nanomater 2012 May; 2012:398302
NIOSHTIC No.
20040822
Abstract
Silicon nanowires (SiNWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 microg of Si NW (~20-30 nm diameter; ~2-15 microm length). Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment. Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time. At day 91 after treatment with the highest doses, lung collagen was increased. Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages. In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung.
Keywords
Biological-effects; Cell-biology; Cellular-reactions; Chemical-properties; Chemical-reactions; Exposure-assessment; Exposure-levels; Exposure-methods; Laboratory-animals; Laboratory-testing; Lung-cells; Particulates; Pulmonary-system; Risk-analysis; Toxic-effects; Toxic-effects; In-vivo-study; Dose-response; Silicon-compounds; Immune-reaction; Pulmonary-clearance
Contact
Jenny R. Roberts, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CAS No.
7440-21-3
Publication Date
20120501
Document Type
Journal Article
Email Address
jur6@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B06062012
ISSN
1687-4110
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Journal of Nanomaterials
State
WV; NY
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