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Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers.

Authors
Elliott-L; Loomis-D; Dement-J; Hein-MJ; Richardson-D; Stayner-L
Source
Occup Environ Med 2012 Jun; 69(6):385-390
NIOSHTIC No.
20040756
Abstract
Objectives: Studies of workers in two US cohorts of asbestos textile workers exposed to chrysotile (North Carolina (NC) and South Carolina (SC)) found increasing risk of lung cancer mortality with cumulative fibre exposure. However, the risk appeared to increase more steeply in SC, possibly due to differences in study methods. The authors conducted pooled analyses of the cohorts and investigated the exposure-disease relationship using uniform cohort inclusion criteria and statistical methods. Methods: Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Poisson regression was used to estimate the exposure-response relationship between asbestos and lung cancer, using both exponential and linear relative rate models adjusted for age, sex, race, birth cohort and decade of follow-up. Results: The cohort included 6,136 workers, contributing 218,631 person-years of observation and 3,356 deaths. Cumulative exposures at the four study facilities varied considerably. The pooled relative rate for lung cancer, comparing 100 f-yr/ml to 0 f-yr/ml, was 1.11 (95% CI 1.06 to 1.16) for the combined cohort, with different effects in the NC cohort (RR = 1.10, 95% CI 1.03 to 1.16) and the SC cohort (RR = 1.67, 95% CI 1.44 to 1.93). Conclusions: Increased rates of lung cancer were significantly associated with cumulative fibre exposure overall and in both the Carolina asbestos-textile cohorts. Previously reported differences in exposure-response between the cohorts do not appear to be related to inclusion criteria or analytical methods.
Keywords
Asbestos-fibers; Lung-cancer; Textile-workers; Textiles; Textiles-industry; Employee-exposure; Mortality-data; Mortality-rates; Cancer; Risk-analysis; Exposure-assessment; Mathematical-models; Statistical-analysis; Surveillance-programs; Demographic-characteristics; Dose-response; Fibrous-bodies
Contact
Dr Leslie Elliott, 984395 Nebraska Medical Center, Omaha, NE 68198-4395, USA
CODEN
OEMEEM
CAS No.
1332-21-4; 12001-29-5
Publication Date
20120601
Document Type
Journal Article
Email Address
leslie.elliott@unmc.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007803; B05222012
Issue of Publication
6
ISSN
1351-0711
NIOSH Division
DSHEFS
Priority Area
Manufacturing
Source Name
Occupational and Environmental Medicine
State
NE; NC; OH; IL
Performing Organization
University of North Carolina, Chapel Hill
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