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Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress.

Authors
Shvedova-AA; Pietroiusti-A; Fadeel-B; Kagan-VE
Source
Toxicol Appl Pharmacol 2012 Jun; 261(2):121-133
NIOSHTIC No.
20040727
Abstract
Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures.
Keywords
Nanotechnology; Hazardous-materials; Toxic-materials; Exposure-assessment; Oxidation; Oxidative-processes; Biochemical-analysis; Biochemical-indicators; Cell-alteration; Cell-damage; Cellular-function; Cellular-reactions; Tissue-disorders; Molecular-biology; Molecular-structure; Cellular-structures; Author Keywords: Carbon nanotubes; Oxidative stress; Oxidative lipidomics; Proteomics; Transcriptomics; Apoptosis
Contact
Anna A. Shvedova, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CODEN
TXAPA9
CAS No.
7440-44-0
Publication Date
20120601
Document Type
Journal Article
Email Address
ats1@cdc.gov
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282; B05102012
Issue of Publication
2
ISSN
0041-008X
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Toxicology and Applied Pharmacology
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
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