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Organochlorines and risk of prostate cancer.

Authors
Ritchie-JM; Vial-SL; Fuortes-LJ; Guo-H; Reedy-VE; Smith-EM
Source
J Occup Environ Med 2003 Jul; 45(7):692-702
NIOSHTIC No.
20040694
Abstract
This pilot study examined the relationships of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) with prostate cancer. Ninety-nine controls were frequency matched by age in 5-year increments to 58 prostate cancer patients. Thirty PCBs and 18 OCPs were measured in serum by gas chromatography. Multiple logistic regression was used to assess the magnitude of association. Seven organochlorines, dieldrin, p,p'-DDE, trans-nonachlor, oxychlordane, heptachlor epoxide, and PCBs 153 and 180 were detected in at least 20% of all study participants. Adjusting for age, body mass index, and a history of prostatitis, oxychlordane and PCB 180 were associated with an increased risk of prostate cancer. This study suggests that long-term, low-dose exposure to specific OCPs and PCBs in the general population may contribute to an increased risk of prostate cancer and supports further investigation in this area.
Keywords
Chromatographic-analysis; Pesticides; Pesticides-and-agricultural-chemicals; Prostate-cancer; Cancer; Exposure-levels; Exposure-limits; Environmental-exposure; Insecticides; Epidemiology; Humans; Men; Age-groups; Polychlorinated-biphenyls; Toxins; Questionnaires; Statistical-analysis; Risk-factors; Blood-serum; Organo-chlorine-compounds
Contact
Justine M. Ritchie, PhD, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242
CODEN
JOEMFM
CAS No.
11097-69-1; 60-57-1; 11097-69-1
Publication Date
20030701
Document Type
Journal Article
Email Address
jritchie@mail.public-health.uiowa.edu
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008491
Issue of Publication
7
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
IA
Performing Organization
University of Iowa
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