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Serum persistent organic pollutants and duration of lactation among Mexican-American women.

Authors
Weldon-RH; Webster-M; Harley-KG; Bradman-A; Fenster-L; Davis-MD; Hubbard-A; Barr-DB; Holland-N; Eskenazi-B
Source
J Environ Public Health 2010 Jun; 2010:861757
NIOSHTIC No.
20040675
Abstract
BACKGROUND: Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation. OBJECTIVES: (1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases associations. METHODS AND RESULTS: We measured selected organochlorines and polychlorinated biphenyls (p, p'-DDE, p, p'-DDT, o, p'-DDT, beta-hexachlorocyclohexane, hexachlorobenzene, and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, Mexican-American pregnant women living in an agricultural region of California and assessed breastfeeding duration by questionnaires. We found no association between DDE, DDT, or estrogenic POPs with shortened lactation duration, but rather associations for two potentially estrogenic POPs with lengthened lactation duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p, p'-DDE & 0.8 [0.6, 1.0] for PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and shortened lactation duration were attributed to a lactation history bias. CONCLUSION: Estrogenic POPs were not associated with shortened lactation duration, but may be associated with longer lactation duration.
Keywords
Lactation; Women; Estrogenic-hormones; Endocrine-function; Endocrine-system; Environmental-contamination; Environmental-exposure; Environmental-pollution; Organic-chemicals; Organic-compounds; Organo-chlorine-compounds; Polychlorinated-biphenyls; Agricultural-workers; Questionnaires
Contact
Brenda Eskenazi, Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
CAS No.
11097-69-1; 50-29-3; 319-85-7; 118-74-1
Publication Date
20100601
Document Type
Journal Article
Email Address
eskenazi@berkeley.edu
Funding Amount
909365
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007400
ISSN
1687-9805
Source Name
Journal of Environmental and Public Health
State
CA; GA
Performing Organization
University of California, Berkeley
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