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Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells.

Authors
Pacurari-M; Qian-Y; Fu-W; Schwegler-Berry-D; Ding-M; Castranova-V; Guo-NL
Source
J Toxicol Environ Health, A 2012 Jan; 75(2):112-128
NIOSHTIC No.
20040650
Abstract
Multiwalled carbon nanotubes (MWCNT) have elicited great interest in biomedical applications due to their extraordinary physical, chemical, and optical properties. Intravenous administration of MWCNT-based medical imaging agents and drugs in animal models was utilized. However, the potential harmful health effects of MWCNT administration in humans have not yet been elucidated. Furthermore, to date, there are no apparent reports regarding the precise mechanisms of translocation of MWCNT into target tissues and organs from blood circulation. This study demonstrates that exposure to MWCNT leads to an increase in cell permeability in human microvascular endothelial cells (HMVEC). The results obtained from this study also showed that the MWCNT-induced rise in endothelial permeability is mediated by reactive oxygen species (ROS) production and actin filament remodeling. In addition, it was found that MWCNT promoted cell migration in HMVEC. Mechanistically, MWCNT exposure elevated the levels of monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule 1 (ICAM-1) in HMVEC. Taken together, these results provide new insights into the bioreactivity of MWCNT, which may have implications in the biomedical application of MWCNT in vascular targeting, imaging, and drug delivery. The results generated from this study also elucidate the potential adverse effects of MWCNT exposure on humans at the cellular level.
Keywords
Animals; Blood-cells; Cell-biology; Cell-function; Cell-wall-permeability; Cellular-function; Environmental-pollution; Kinetics; Metabolism; Microbiology; Drug-receptor; Antioxidants
Contact
N. L. Guo, Mary Babb Randolph Cancer Center and Department of Community Medicine,West Virginia University, Morgantown, WV 26506-9300
CODEN
JTEHD6
Publication Date
20120101
Document Type
Journal Article
Email Address
lguo@hsc.wvu.edu
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B04252012
Issue of Publication
2
ISSN
1528-7394
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
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