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Exposure to repetitive tasks induces motor changes related to skill acquisition and inflammation in rats.

Authors
Kietrys-DM; Barr-AE; Barbe-MF
Source
J Mot Behav 2011 Nov; 43(6):465-476
NIOSHTIC No.
20040638
Abstract
The authors elucidate exposure-response relationships between repetitive tasks, inflammation, and motor changes with work-related musculoskeletal disorders. Using a rat model of reaching and handle pulling, they examined effects of performing a high-repetition, low-force (HRLF); low-repetition, high-force (LRHF); or high-repetition, high-force (HRHF) task (2 hr/day, 3 days/week, 12 weeks) on reach rate and force, percentage of successful reaches, duration of participation, and grip strength. Reach rate and reach force improved with HRLF, and percentage success increased in all groups in Week 9, and in HRLF and HRHF in Week 12, indicative of skill acquisition. Duration and grip strength showed force-dependent declines with task performance. A subset of HRHF rats received ibuprofen in Weeks 5-12. Ibuprofen significantly improved reach rate, reach force, and duration in treated rats, indicative of an inflammatory influence on reach performance. Ibuprofen improved percentage of successful reaches in Week 9, although this increase was not sustained. However, declines in grip strength, a nocifensive behavior, were not prevented by ibuprofen. Examination of cervical spinal cords of untreated and ibuprofen treated HRHF rats showed increased IL-1beta, an inflammatory cytokine, in neurons. These findings suggest that only a preventive intervention could have addressed all motor declines.
Keywords
Laboratory-animals; Animals; Pharmacology; Exposure-levels; Musculoskeletal-system; Musculoskeletal-system-disorders; Workers; Physical-capacity; Physiological-factors; Physiological-function; Physiology; Pharmacology; Physiopathology; Behavior; Cumulative-trauma; Cumulative-trauma-disorders; Author Keywords: repetitive task; work-related musculoskeletal disorders; grip strength; reach performance; Cumulative-trauma; Cumulative-trauma-disorders
CODEN
JMTBAB
Publication Date
20111101
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003970
Issue of Publication
6
ISSN
0022-2895
Source Name
Journal of Motor Behavior
State
NJ; OR; PA
Performing Organization
Temple University
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