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Applications of nanotechnology in dermatology.

Authors
DeLouise-LA
Source
J Invest Dermatol 2012 Mar; 132(3)(Pt 2):964-975
NIOSHTIC No.
20040637
Abstract
What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintentional nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease outweigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.
Keywords
Nanotechnology; Skin; Skin-exposure; Environmental-exposure; Cosmetics; Humans; Men; Women; Diseases; Dermatology
Contact
Lisa A. DeLouise, Department of Biomedical Engineering, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642
CODEN
JIDEAE
Publication Date
20120301
Document Type
Journal Article
Email Address
Lisa_DeLouise@urmc.rochester.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R21-OH-009970; B04252012
Issue of Publication
3
ISSN
0022-202X
Source Name
Journal of Investigative Dermatology
State
NY
Performing Organization
University of Rochester, New York
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