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Dermal absorption of finite doses of volatile compounds.

Authors
Frasch-HF
Source
J Pharm Sci 2012 Jul; 101(7):2616-2619
NIOSHTIC No.
20040635
Abstract
Laplace domain solutions to a previously published finite dose skin diffusion model are presented. The purpose of the current analysis is to derive a simple algebraic expression quantifying the total mass that is systemically absorbed at infinite time after exposure, relative to the applied mass. The resulting expression is a function of two dimensionless parameters: f, the fractional depth within the skin surface through which the permeant is initially deposited, and ?, the ratio of maximum evaporation flux to maximum dermal flux. The result may be useful for dermal risk assessment as well as in the evaluation of cosmetic and pharmaceutical product performance.
Keywords
Skin; Skin-absorption; Exposure-levels; Exposure-limits; Absorption-rates; Mathematical-models; Diffusion-analysis; Models; Risk-analysis; Risk-factors; Volatiles; Author Keywords: diffusion; mathematical model; percutaneous; permeability; skin; solvent evaporation; absorption
Contact
H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
CODEN
JPMSAE
Publication Date
20120701
Document Type
Journal Article
Email Address
hfrasch@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B04252012
Issue of Publication
7
ISSN
0022-3549
NIOSH Division
HELD
Priority Area
Manufacturing; Services
Source Name
Journal of Pharmaceutical Sciences
State
WV
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