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Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai.

Authors
Agalliu-I; Costello-S; Applebaum-KM; Ray-RM; Astrakianakis-G; Gao-DL; Thomas-DB; Checkoway-H; Eisen-EA
Source
Cancer Causes Control 2011 Oct; 22(10):1397-1404
NIOSHTIC No.
20040603
Abstract
OBJECTIVE: Exposure to endotoxin has been consistently associated with a reduced risk of lung cancer. However, there is a paucity of information regarding temporal aspects of this relationship. The objective of this study was to investigate the associations between contiguous windows of endotoxin exposure and risk of lung cancer. METHODS: Data were reanalyzed from a case-cohort study (602 cases, 3,038 subcohort) of female textile workers in Shanghai, China. Cumulative endotoxin exposure was partitioned into two windows: =20 and <20 years before risk. Exposure-response relations were examined using categorical and non-linear (semi-parametric) models, accounting for confounding by previous exposure windows. RESULTS: There was an inverse trend of decreasing risk of lung cancer associated with increasing levels of endotoxin exposure =20 years before risk (p trend = 0.02). Women in the highest two categories of cumulative exposures had hazard ratios of 0.78 (95% CI 0.60-1.03) and 0.77 (95% CI 0.58-1.02) for lung cancer, respectively, in comparison with unexposed textile workers. There was, however, a weaker association and not statistically significant between lung cancer and endotoxin exposure accumulated in the more recent window (<20 years before risk). CONCLUSION: Results provide further evidence that endotoxin exposure that occurred 20 years or more before risk confers the strongest protection against lung cancer, indicating a possible early anti-carcinogenic effect. Further studies are needed to better understand the underlying biological mechanisms for this effect.
Keywords
Epidemiology; Statistical-analysis; Endotoxins; Lung; Lung-disease; Lung-disorders; Lung-cancer; Cancer; Neoplasms; Age-groups; Exposure-levels; Exposure-limits; Risk-factors; Textiles-industry; Microbiology; Author Keywords: Lung cancer; Endotoxin; Exposure windows; Exposure response models; Latency; Case-cohort analysis; Non-parametric models; Splines
Contact
IIir Agalliu, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave., Belfer Bldg Room 1315-B, Bronx, NY
CODEN
CCCNEN
Publication Date
20111001
Document Type
Journal Article
Email Address
ilir.agalliu@einstein.yu.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009390
Issue of Publication
10
ISSN
0957-5243
Source Name
Cancer Causes and Control
State
NY; CA; MA; WA
Performing Organization
Boston University Medical Campus
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